Missouri

Highlights

• #17 of 50: Talent
• #18 of 50: Scale-ups
• #24 of 50: Venture capital

The seven inputs

Each input is a z-score against the other states: 0 is the average state, and each step is one standard deviation (capped at ±3). Ranks are among the 50 states.

• Venture capital -0.1 #24 of 50
• Startup formation 0.0 #25 of 50
• Scale-ups +0.2 #18 of 50
• Economic output and wealth -0.5 #37 of 50
• Innovation and patents -0.2 #31 of 50
• Talent +0.4 #17 of 50
• Momentum -0.3 #30 of 50

Top companies

The largest companies headquartered in Missouri, by latest annual revenue.

1. Centene Corporation CNC · Healthcare · Clayton · St. Louis, MO-IL metro $195B
2. Bunge Global SA BG · Consumer Staples · Chesterfield · St. Louis, MO-IL metro $70.3B
3. Enterprise Mobility Private · Services · St. Louis, MO-IL $38.0B
4. Reinsurance Group of America, Inc. RGA · Financials · Chesterfield · St. Louis, MO-IL metro $23.7B
5. World Wide Technology Private · IT Software & Services · Maryland Heights · St. Louis, MO-IL metro $20.0B

Roots Density Data, All Companies (public: SEC filings; private: Forbes Top Private Companies 2025). Ranked by latest annual revenue.

Metros in Missouri

• Columbia, MO #29 of 109 metros 55
• St. Louis, MO-IL #31 of 109 metros 54
• Kansas City, MO-KS #55 of 109 metros 43
• Springfield, MO #91 of 109 metros 19